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X染色体开放阅读框21抗体
半岛bd体育手机客户端 介绍
靶标：
Tasl 半岛bd体育手机客户端 别名： 5430427O19Rik； Tasl； TLR adaptor interacting with endolysosomal SLC15A4； TLR adaptor interacting with endolysosomal SLC15A4； TLR adapter interacting with SLC15A4 on the lysosome； protein CXorf21 homolog； uncharacterized protein CXorf21 homolog； X染色体开放阅读框21； 吲哚1； 背景信息：
Innate immune adapter that mediates the recruitment and activation of IRF5 downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9. Following recruitment to endolysosome by SLC15A4 downstream of TLR7, TLR8 and TLR9, specifically recruits IRF5 transcription factor via its pLxIS motif, leading to IRF5 activation and subsequent expression of type I interferons. Plays a role in the regulation of endolysosomal pH in immune cells such as B-cells, dendritic cells and monocytes.
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