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DNAJB14蛋白抗体
半岛bd体育手机客户端 介绍
靶标:
Dnajb14 半岛bd体育手机客户端 别名: 5730496F10Rik; Dnajb14; DnaJ heat shock protein family (Hsp40) member B14; DnaJ heat shock protein family (Hsp40) member B14; dnaJ homolog subfamily B member 14; DnaJ (Hsp40) homolog, subfamily B, member 14; DNAJB14蛋白; 背景信息:
Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD pathway. Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities. Can also act independently of HSPA8/Hsc70: together with DNAJB12, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers. While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70. When overexpressed, forms membranous structures together with DNAJB12 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear.
宿主:Rbt |
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