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着丝粒蛋白S抗体
半岛bd体育手机客户端 介绍
靶标:
Cenps 半岛bd体育手机客户端 别名: 2610040C18Rik; 2810407L01Rik; Apitd1; CENP-S; Cenps; centromere protein S; centromere protein S; centromere protein S; FANCM-interacting histone fold protein 1; apoptosis-inducing TAF9-like domain-containing protein 1 homolog; apoptosis-inducing, TAF9-like domain 1; ortholog of human apoptosis-inducing, TAF9-like domain 1 APITD1; 着丝粒蛋白S; 背景信息:
This gene was identified in the neuroblastoma tumor suppressor candidate region on chromosome 1p36. It contains a TFIID-31 domain, similar to that found in TATA box-binding protein-associated factor, TAF(II)31, which is required for p53-mediated transcription activation. This gene was expressed at very low levels in neuroblastoma tumors, and was shown to reduce cell growth in neuroblastoma cells, suggesting that it may have a role in a cell death pathway. The protein is a component of multiple complexes, including the Fanconi anemia (FA) core complex, the APITD1/CENPS complex, and the CENPA-CAD (nucleosome distal) complex. Known functions include an involvement with chromatin associations of the FA core complex, and a role in the stable assembly of the outer kinetochore. Alternative splicing of this gene results in multiple transcript variants. Naturally occurring read-through transcripts also exist
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