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IQCG蛋白抗体
半岛bd体育手机客户端 介绍
靶标:
Iqcg 半岛bd体育手机客户端 别名: 2400003L07Rik; G1-374-12; esgd12d; repro1; stubby12d; Iqcg; IQ motif containing G; IQ motif containing G; dynein regulatory complex protein 9; IQ domain-containing protein G; IQCG蛋白; 背景信息:
IQCG is a 443 amino acid protein containing one IQ domain. Widely distributed in nature, the IQ domain forms an amphiphilic seven-turn ?-helix capable of binding calmodulin in a Ca2+-independent manner. The level of intracellular calcium is tightly regulated in all eukaryotic cells. A modest increase in this level can result in a myriad of physiological responses, most of which are mediated by calmodulin (CaM), the universal calcium sensor. In acute T-lymphoid myeloid leukemia, IQCG forms a complex with Nup98, an O-linked glycoprotein and a component of the nuclear pore complex. NUP98-IQCG complex bind co-activators and or co-repressors, which suggest a role in transcriptional regulation.Nup98-IQCG complex inhibits 32Dcl3 cell apoptosis induced by Arabinofuranosylcytosine (Ara-C) and partially blocks granulocyte differentiation induced by G-CSF. IQCG exists as two isoforms due to alternatively splicing events.
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