抗体 >> 其他抗体
9号染色体开放阅读框116抗体
半岛bd体育手机客户端 介绍
靶标：
Pierce1 半岛bd体育手机客户端 别名： 1700007K13Rik； Rbest47； Pierce1； piercer of microtubule wall 1； piercer of microtubule wall 1； piercer of microtubule wall 1 protein； UPF0691 protein C9orf116 homolog； p53-induced expression in RB-null cells protein 1； pierce 1； 9号染色体开放阅读框116； 背景信息：
C9orf116, also known as PIERCE1. PIERCE1 is an important p53 target gene contributing to normal DNA damage response and may play crucial roles in maintaining genomic integrity against genotoxic stresses, including UVC irradiation. PIERCE1 exists as two alternatively spliced isoforms and is predominantly expressed in human small cell lung cancer. PIERCE1 knockdown induces down-regulation of proapoptotic genes including Ei24, Apaf1 and PTEN, suggesting that PIERCE1 is a proapoptotic gene. It is helpful for in-depth understanding of p53 pathways and the design of new cancer therapies.
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