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软骨基质相关蛋白UCMA抗体
半岛bd体育手机客户端 介绍
靶标:
Ucma 半岛bd体育手机客户端 别名: 1110017I16Rik; AW121955; Grp; Ucma; upper zone of growth plate and cartilage matrix associated; upper zone of growth plate and cartilage matrix associated; unique cartilage matrix-associated protein; Gla-rich protein; upper zone of growth plate and cartilage matrix associated protein; 软骨基质相关蛋白UCMA; 背景信息:
UCMA is a 138 amino acid secreted protein that is highly expressed in resting chrondrocytes in developing long bones and is thought to function in the early phase of chrondrocyte differentiation. A furin-like protease processes UCMA into an N-terminal 37 amino acid peptide and a C-terminal 74 amino acid peptide, which is referred to as Unique cartilage matrix-associated protein C-terminal fragment (Ucma-C). Introduction of recombinant Ucma-C interferes with osteogenic differentiation of mesenchymal stem cells, MC3T3-E1 preosteoblasts and primary osteoblasts. This suggests that Ucma may be involved in the negative regulation of osteogenic differentiation of osteochondrogenic precursor cells at the cartilage-bone interface and in peripheral zones of fetal cartilage.
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