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锌指蛋白结构域ZFYVE21抗体
半岛bd体育手机客户端 介绍
靶标:
Zfyve21 半岛bd体育手机客户端 别名: 1110013H04Rik; AW558780; C85416; Zfyve21; zinc finger, FYVE domain containing 21; zinc finger, FYVE domain containing 21; zinc finger FYVE domain-containing protein 21; 锌指蛋白结构域ZFYVE21; 背景信息:
ZF21 Antibody: ZF21 was initially identified as protein that could bind to the cytoplasmic tail of MT1-MMP (Membrane-type 1 matrix metalloproteinase), a potent invasion-promoting protease. ZF21 is a member of a protein family characterized by the presence of a phosphatidylinositol 3-phosphate-binding FYVE domain and regulates focal adhesions (FAs) and cell movement. Knockdown of ZF21 expression resulted in a delay of FA disassembly following induction of synchronous disassembly of FAs by nocodazole treatment, suggesting that ZF21 is involved in FA disassembly. ZF21 contains a noncanonical pleckstrin homology domain that is a possible therapeutic target to treat metastatic cancer.
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