试剂 半岛游戏平台官网入口网址 设备 原料
银牌会员第 1
访问量: 848786 网址:www.vuestras.com/show1000160 在线留言
半岛bd体育手机客户端 搜索
抗体 >> 其他抗体
NSMCE1蛋白抗体
NSMCE1蛋白抗体图片
交货期: 1周
索取资料及报价
交货期: 1周
半岛bd体育手机客户端 别名: Anti-Nsmce1
Anti-NSE1 homolog, SMC5-SMC6 complex component Antibody
半岛bd体育手机客户端 介绍
靶标:

Nsmce1


半岛bd体育手机客户端 别名:

2510027N19Rik; Nsmce1; NSE1 homolog, SMC5-SMC6 complex component; NSE1 homolog, SMC5-SMC6 complex component; non-structural maintenance of chromosomes element 1 homolog; non-SMC element 1 homolog; NSMCE1蛋白;


背景信息:
RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. Involved in maintenance of genome integrity, DNA damage response and DNA repair. NSMCE3/MAGEG1 and NSMCE1 ubiquitin ligase are components of SMC5-SMC6 complex and may positively regulate homologous recombination-mediated DNA repair. MAGEF1-NSMCE1 ubiquitin ligase promotes proteasomal degradation of MMS19, a key component of the cytosolic iron-sulfur protein assembly (CIA machinery. Down-regulation of MMS19 impairs the activity of several DNA repair and metabolism enzymes such as ERCC2/XPD, FANCJ, RTEL1 and POLD1 that require iron-sulfur clusters as cofactors.

宿主:Rbt
类型:Pab
同种型:IgG
应用:WB
纯化方式:亲和纯化
偶联物:Unconjugated
性状:液体
存储溶液:参阅说明书
浓度:Batch dependent (Please refer to the vial label for the specific concentration.)
稀释比例: Optimal dilutions/concentrations should be determined by the end user
储存:经常使用则4°C保存。-20°C保存不超过两年。避免反复冻融。
注意事项:仅供实验室使用。不适用于人类或动物的任何临床,治疗或诊断用途。不适合动物或人类食用。

相关半岛bd体育手机客户端
我要咨询 关闭
  • 姓名*
  • 电话*
  • 单位*
  • email
  • 留言内容*
  • 验证码*
  • 让更多商家关注
  • Baidu
    map