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锌指蛋白Zdhhc12抗体
半岛bd体育手机客户端 介绍
靶标：
Zdhhc12 半岛bd体育手机客户端 别名： 1190004A01Rik； Zdhhc12； zinc finger, DHHC domain containing 12； zinc finger, DHHC domain containing 12； palmitoyltransferase ZDHHC12； DHHC domain-containing cysteine-rich protein 12； DHHC-12； probable palmitoyltransferase ZDHHC12； zinc finger DHHC domain-containing protein 12； 锌指蛋白Zdhhc12； 背景信息：
ZDHHC12 (Zinc Finger DHHC-Type Palmitoyltransferase 12) is a Protein Coding gene. The ZDHHC12 gene, located on 9q34.11, is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, and frog. ZDHHC12 belongs to the DHHC palmitoyltransferase family. 3 alternatively spliced human isoforms have been reported. ZDHHC12 is widely expressed in the colon, stomach, and other tissues. ZDHHC12-mediated S-palmitoylation promotes the cell membrane localization of claudin-3 (CLDN3) and maintains its stability in ovarian cancer cells, contributing to the oncoprotein function of CLDN3. Targeting ZDHHC12-mediated CLDN3 S-palmitoylation might be a potential strategy for ovarian cancer therapy. 225 organisms have orthologs with the human gene ZDHHC12.
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