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拓扑异构酶相关功能蛋白4-2抗体
拓扑异构酶相关功能蛋白4-2抗体图片
交货期: 1周
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交货期: 1周
半岛bd体育手机客户端 别名: Anti-TENT4B
Anti-terminal nucleotidyltransferase 4B Antibody
半岛bd体育手机客户端 介绍
靶标:

TENT4B


半岛bd体育手机客户端 别名:

PAPD5; TRF4-2; TUT3; TENT4B; terminal nucleotidyltransferase 4B; terminal nucleotidyltransferase 4B; terminal nucleotidyltransferase 4B; PAP associated domain containing 5; PAP-associated domain-containing protein 5; TUTase 3; non-canonical poly(A) RNA polymerase PAPD5; poly(A) RNA polymerase D5, non-canonical; terminal guanylyltransferase; terminal nucleotidyltransferase 4A; terminal uridylyltransferase 3; topoisomerase-related function protein 4-2; 拓扑异构酶相关功能蛋白4-2;


背景信息:
Terminal nucleotidyltransferase that catalyzes preferentially the transfert of ATP and GTP on RNA 3' poly(A tail creating a heterogeneous 3' poly(A tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation. Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity (in vitro. Required for cytoplasmic polyadenylation of mRNAs involved in carbohydrate metabolism, including the glucose transporter SLC2A1/GLUT1. Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion. Mediates 3' adenylation of the microRNA MIR21 followed by its 3'-to-5' trimming by the exoribonuclease PARN leading to degradation. Mediates 3' adenylation of H/ACA box snoRNAs (small nucleolar RNAs followed by its 3'-to-5' trimming by the exoribonuclease PARN which enhances snoRNA stability and maturation.

宿主:Rbt
类型:Pab
同种型:IgG
应用:WB
纯化方式:亲和纯化
偶联物:Unconjugated
性状:液体
存储溶液:参阅说明书
浓度:Batch dependent (Please refer to the vial label for the specific concentration.)
稀释比例: Optimal dilutions/concentrations should be determined by the end user
储存:经常使用则4°C保存。-20°C保存不超过两年。避免反复冻融。
注意事项:仅供实验室使用。不适用于人类或动物的任何临床,治疗或诊断用途。不适合动物或人类食用。

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