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Pellino 2蛋白抗体
半岛bd体育手机客户端 介绍
靶标：
PELI2 半岛bd体育手机客户端 别名： PELI2； pellino E3 ubiquitin protein ligase family member 2； pellino E3 ubiquitin protein ligase family member 2； E3 ubiquitin-protein ligase pellino homolog 2； RING-type E3 ubiquitin transferase pellino homolog 2； pellino homolog 2； pellino-2； protein pellino homolog 2； Pellino 2蛋白； 背景信息：
PELI2 is a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. It is involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. It mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. It may be important for LPS- and IL1B-induced MAP3K7- dependent, but not MAP3K3-dependent, NF-kappa-B activation. And it can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1.
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