半岛bd体育手机客户端 介绍
靶标:
BMAL2 半岛bd体育手机客户端 别名: ARNTL2; CLIF; MOP9; PASD9; bHLHe6; BMAL2; basic helix-loop-helix ARNT like 2; basic helix-loop-helix ARNT like 2; aryl hydrocarbon receptor nuclear translocator-like protein 2; CYCLE-like factor; PAS domain-containing protein 9; aryl hydrocarbon receptor nuclear translocator like 2; basic-helix-loop-helix-PAS protein MOP9; brain and muscle ARNT-like 2; class E basic helix-loop-helix protein 6; member of PAS protein 9; member of PAS superfamily 9; transcription factor BMAL2; 芳香烃受体核转录蛋白样2; 背景信息:
Aryl hydrocarbon receptor nuclear translocator-like 2, also known as Mop9, Bmal2, Clif, or Arntl2, is a gene. This gene encodes a basic helix-loop-helix transcription factor belonging to the PAS (PER, ARNT, SIM) superfamily. The PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations in light and temperature. This protein forms a transcriptionally active heterodimer with the circadian CLOCK protein, the structurally related MOP4, and hypoxia-inducible factors, such as HIF1alpha. Consistent with its role as a biologically relevant partner of circadian and hypoxia factors, this protein is coexpressed in regions of the brain such as the thalamus, hypothalamus, and amygdala. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
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