半岛bd体育手机客户端 介绍
靶标:
Slc37a2 半岛bd体育手机客户端 别名: G3PP; Slc37a1; cI-2; ci2; Slc37a2; solute carrier family 37 (glycerol-3-phosphate transporter), member 2; solute carrier family 37 (glycerol-3-phosphate transporter), member 2; glucose-6-phosphate exchanger SLC37A2; cAMP inducible 2 protein; cAMP inducible gene 2; cAMP-inducible protein 2; solute carrier family 37 (glycerol-3-phosphate transporter), member 1; solute carrier family 37 member 2; sugar phosphate exchanger 2; 溶质载体转运蛋白家族37成员A2; 背景信息:
The Slc37 gene family consists of four members which have 10-12 predicted transmembrane domains and belong to the sugar-phosphate transporter superfamily. Recent experiments have demonstrated that Slc37A2 is a macrophage-specific gene selectively expressed in obese white adipose tissue. Its transcript is also expressed in spleen and thymus and the cell lines RAW264.7 and THP-1. Compared to wild-type mice, Slc37A2 mRNA is expressed at nine-fold higher levels in abdominal epididymal fat deposits of ob/ob mice, suggesting that it may be required to limit the contribution of macrophages to the inflammatory state present in obesity. Slc37A2 protein is post-translationally modified with the addition of N-linked glycans and migrates as a heterogeneous species of 50-75kDa.
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