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多胺调制因子结合蛋白1抗体
半岛bd体育手机客户端 介绍
靶标：
Pmfbp1 半岛bd体育手机客户端 别名： 1700016D22Rik； F77； Stap； Pmfbp1； polyamine modulated factor 1 binding protein 1； polyamine modulated factor 1 binding protein 1； polyamine-modulated factor 1-binding protein 1； PMF-1-binding protein； sperm tail-associated protein； 多胺调制因子结合蛋白1； 多胺调节因子1结合蛋白1(PMFBP1)； 背景信息：
PMF-1 is a 205 amino acid protein involved in kinetochore formation. Localized to the nucleus, PMF-1 contains a coiled-coil domain which interacts with the leucine-zipper domain of Nrf2. This interaction regulates the transcription of SSAT, a regulatory enzyme for polyamine catabolism. PMF-1 is also a component of the MIS12 complex, which is required for kinetochore formation and chromosomal alignment and segregation. PMF-1 is expressed at highest levels in skeletal muscle and heart, with moderate expression in liver and kidney. PMFBP1 (Polyamine-modulated factor 1-binding protein 1) is a 1022 amino acid protein that binds PMF-1 and may be involved in general organization of the cytoskeleton. Due to evidence that PMFBP1 may play a role in sperm tail morphology, it may therefore affect fertility. There are three isoforms of PMFBP1 that are produced as a result of alternative splicing events.
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