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原钙粘附蛋白α1抗体
半岛bd体育手机客户端 介绍
靶标:
PCDHA1 半岛bd体育手机客户端 别名: PCDH-ALPHA1; PCDHA1; protocadherin alpha 1; protocadherin alpha 1; protocadherin alpha-1; KIAA0345-like 13; PCDH-alpha-1; 原钙粘附蛋白α1; 原钙黏素α1(PCDHa1); 背景信息:
This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008],
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