半岛bd体育手机客户端 介绍
靶标：
ZNF395 半岛bd体育手机客户端 别名： HDBP-2； HDBP2； HDRF-2； PBF； PRF-1； PRF1； Si-1-8-14； ZNF395； zinc finger protein 395； zinc finger protein 395； zinc finger protein 395； HD gene regulatory region-binding protein 2； HD-regulating factor 2； Huntington's disease gene regulatory region-binding protein 2； huntington disease gene regulatory region-binding protein 2； papillomavirus regulatory factor 1； papillomavirus regulatory factor PRF-1； papillomavirus-binding factor； 锌指蛋白395； 背景信息：
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. As a member of the krueppel C2H2-type zinc-finger protein family, ZNF395 (Zinc finger protein 395), also known as PBF (Papillomavirus-binding factor) and HDBP2 (Huntington disease gene regulatory region-binding protein 2), is a 513 amino acid protein that contains one C2H2-type zinc finger. ZNF395 binds to the 3??-CCGG-5?? sequence within the papillomavirus promoter adjacent to a RUNX1-binding motif. It has also been established that ZNF395 binds to a seven base pair region within the Huntington's disease (HD) gene promoter, an essential element for HD gene expression. ZNF395 is widely expressed and probably shuttles between the nucleus and cytoplasm.
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