半岛bd体育手机客户端 介绍
靶标：
SPTLC3 半岛bd体育手机客户端 别名： C20orf38； LCB 3； LCB2B； LCB3； SPT 3； SPT3； SPTLC2L； dJ718P11； dJ718P11.1； hLCB2b； SPTLC3； serine palmitoyltransferase long chain base subunit 3； serine palmitoyltransferase long chain base subunit 3； serine palmitoyltransferase 3； long chain base biosynthesis protein 2b； long chain base biosynthesis protein 3； serine palmitoyltransferase, long chain base subunit 2-like (aminotransferase 2)； serine-palmitoyl-CoA transferase 3； 丝氨酸棕榈酰转移酶长链碱性亚基3(SPTLC3)； 背景信息：
The SPTLC3 gene encodes an isoform of the third subunit of serine palmitoyltransferase (SPT; EC 2.3.1.50), which catalyzes the rate-limiting step of the de novo synthesis of sphingolipids (Hornemann et al., 2006 [PubMed 17023427]). SPT contains 2 main subunits: the common SPTLC1 subunit (MIM 605712) and either SPTLC2 (MIM 605713) or its isoform SPTLC2L (SPTLC3), depending on the tissue in which biosynthesis occurs (Hornemann et al., 2006 [PubMed 17023427]). There are also 2 highly related isoforms of a third subunit, SSSPTA (MIM 613540) and SSSPTB (MIM 610412), that confer acyl-CoA preference of the SPT enzyme and are essential for maximal enzyme activity (Han et al., 2009 [PubMed 19416851]).[supplied by OMIM, Nov 2010],
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