试剂 半岛游戏平台官网入口网址 设备 原料
银牌会员第 1
访问量: 865371 网址:www.vuestras.com/show1000160 在线留言
半岛bd体育手机客户端 搜索
抗体 >> 其他抗体
粘脂蛋白3抗体
粘脂蛋白3抗体图片
交货期: 1周
索取资料及报价
交货期: 1周
半岛bd体育手机客户端 别名: Anti-MCOLN3
Anti-mucolipin TRP cation channel 3 Antibody
半岛bd体育手机客户端 介绍
靶标:

MCOLN3


半岛bd体育手机客户端 别名:

TRP-ML3; TRPML3; MCOLN3; mucolipin TRP cation channel 3; mucolipin TRP cation channel 3; mucolipin-3; mucolipin 3; transient receptor potential channel mucolipin 3; 粘脂蛋白3;


背景信息:
The endolysosome system takes part in important cellular functions such as membrane trafficking, protein transport, autophagy and signal transduction. Endosomes result from endocytosis of the plasma membrane and lysosomes (which are derived from late endosomes) conatin mainly hydrolytic enzymes and generally have a low internal pH. Like the endoplasmic reticulum (ER), endolysosomes also store Ca2+ (luminal Ca2+ concentration: 0.5 mM), and similarly to Ca2+ release from the ER, Ca2+ from endolysosomes may also play an important role in various signaling events. To date such candidates include members of the TRP super-family of ion channels and the two-pore Ca2+ channels (TPCs). TRPMLs, also termed mucolipins, are members of the TRP channels. In mammals, three TRPMLs are known to date (TRPML1-3 or MCOLN1-3). They are all localized to endolysosomes, although when over expressed in heterologous systems, TRPML3 is found on the plasma membrane. These channels are Ca2+ permeable and display inward rectifying current properties. Like all members of this family, TRPMLs have six transmembrane domains and intracellular N- and C-termini (relatively short tails compared to other members). They are characterized by an exceptionally large extracellular (luminal) loop between transmembrane domains 1 and 2, and N-glycosylation sites are present in the first extracellular (luminal) loop. In mammals, TRPML1 is expressed in a ubiquitous manner and shows highest expression in the brain, kidney, spleen, liver and heart. TRPML2 and TRPML3 are less widely expressed. Interestingly, in mouse, two splice variants exist for TRPML2. The shorter variant is more broadly expressed and is dominant over the longer variant in the thymus, spleen and kidney. TRPML3 is highly detected in the thymus, lung, kidney, spleen and eye, some epithelial cells and brain. Pathologies related to these channels include type IV mucolipidosis, a neurodegenetative disease characterized by retardation and retinal degeneration caused by a loss of function mutation in the gene encoding TRPML1. In contrast, a gain of function mutation in TRPML3, in mice, causes deafness, and pigmentation defects.

宿主:Rbt
类型:Pab
同种型:IgG
应用:WB
纯化方式:亲和纯化
偶联物:Unconjugated
性状:液体
存储溶液:参阅说明书
浓度:Batch dependent (Please refer to the vial label for the specific concentration.)
稀释比例: Optimal dilutions/concentrations should be determined by the end user
储存:经常使用则4°C保存。-20°C保存不超过两年。避免反复冻融。
注意事项:仅供实验室使用。不适用于人类或动物的任何临床,治疗或诊断用途。不适合动物或人类食用。

相关半岛bd体育手机客户端
我要咨询 关闭
  • 姓名*
  • 电话*
  • 单位*
  • email
  • 留言内容*
  • 验证码*
  • 让更多商家关注
  • Baidu
    map