半岛bd体育手机客户端 介绍
靶标：
MARCHF1 半岛bd体育手机客户端 别名： MARCH-I； MARCH1； RNF171； MARCHF1； membrane associated ring-CH-type finger 1； membrane associated ring-CH-type finger 1； E3 ubiquitin-protein ligase MARCHF1； E3 ubiquitin-protein ligase MARCH1； RING finger protein 171； RING-type E3 ubiquitin transferase MARCH1； RING-type E3 ubiquitin transferase MARCHF1； membrane associated ring finger 1； membrane-associated RING finger protein 1； membrane-associated RING-CH protein I； membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase； 膜相关环指蛋白1； 背景信息：
MARCH1 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH1 downregulates the surface expression of major histocompatibility complex (MHC) class II molecules (see MIM 142880) and other glycoproteins by directing them to the late endosomal/lysosomal compartment (Bartee et al., 2004 [PubMed 14722266]; Thibodeau et al., 2008 [PubMed 18389477]; De Gassart et al., 2008 [PubMed 18305173]).[supplied by OMIM, Mar 2010],
宿主：Rbt |
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