半岛bd体育手机客户端 介绍
靶标：
ADPRS 半岛bd体育手机客户端 别名： ADPRHL2； ARH3； CONDSIAS； ADPRS； ADP-ribosylserine hydrolase； ADP-ribosylserine hydrolase； ADP-ribosylhydrolase ARH3； ADP-ribose glycohydrolase ARH3； ADP-ribosylarginine hydrolase like 2； ADP-ribosylhydrolase 3； ADP-ribosylhydrolase like 2； O-acetyl-ADP-ribose deacetylase ARH3； [Protein ADP-ribosylarginine] hydrolase-like protein 2； [Protein ADP-ribosylserine] hydrolase； poly(ADP-ribose) glycohydrolase ARH3； protein ADP-ribosylarginine hydrolase-like protein 2； 背景信息：
This gene encodes a member of the ADP-ribosylglycohydrolase family. The encoded enzyme catalyzes the removal of ADP-ribose from ADP-ribosylated proteins. This enzyme localizes to the mitochondria, in addition to the nucleus and cytoplasm. Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism may be required for maintenance of the normal function of neuronal cells. Generates ADP-ribose from poly-(ADP-ribose), but does not hydrolyze ADP-ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds. Due to catalytic inactivity of PARG mitochondrial isoforms, ARH3 is the only PAR hydrolyzing enzyme in mitochondria.
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