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血管紧张素激活蛋白1抗体
半岛bd体育手机客户端 介绍
靶标:
ELP6 半岛bd体育手机客户端 别名: C3orf75; TMEM103; ELP6; elongator acetyltransferase complex subunit 6; elongator acetyltransferase complex subunit 6; elongator complex protein 6; UPF0405 protein C3orf75; angiotonin-transactivated protein 1; elongator complex protein 6 homolog; transmembrane protein 103; 血管紧张素激活蛋白1; 背景信息:
c3orf75 (TMEM103, ATP1, Q9NXJ3, AK000218, FLJ20211 and most recently, ELP6) is a conserved open reading frame within human chromosome 3. c3ORF75 was recently reported to encode ELP6, a subunit of the Elongator complex, and to have a function in cell migration and tumorigenicity. Conserved from yeast to humans, Elongator is a protein complex implicated in multiple processes including transcription regulation, α-tubulin acetylation, and tRNA modification, and its defects have been shown to cause human diseases such as familial dysautonomia. Elongator consists of two copies of six core subunits (Elp1, Elp2, Elp3, Elp4, Elp5, and Elp6) that are organized into two subcomplexes: Elp1/2/3 and Elp4/5/6 and form a stable assembly of 850 kDa in size.
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