半岛bd体育手机客户端 介绍
靶标：
UGT1A4 半岛bd体育手机客户端 别名： GNT1； HUG-BR2； UDPGT； UDPGT 1-4； UGT-1A； UGT-1D； UGT1； UGT1-01； UGT1-04； UGT1.1； UGT1.4； UGT1A； UGT1A1； UGT1A4S； UGT1D； hUG-BR1； UGT1A4； UDP glucuronosyltransferase family 1 member A4； UDP glucuronosyltransferase family 1 member A4； UDP-glucuronosyltransferase 1A4； Bilirubin-specific UDPGT isozyme 1； UDP glucuronosyltransferase 1 family, polypeptide A4； UDP glycosyltransferase 1 family, polypeptide A4； UDP-glucuronosyltransferase 1 family polypeptide A4s； UDP-glucuronosyltransferase 1-1； UDP-glucuronosyltransferase 1-4； UDP-glucuronosyltransferase 1-A； UDP-glucuronosyltransferase 1-D； UDP-glucuronosyltransferase 1A1； UDPGT 1-1； bilirubin UDP-glucuronosyltransferase isozyme 2； bilirubin-specific UDPGT isozyme 2； 背景信息：
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. This enzyme has some glucuronidase activity towards bilirubin, although is is more active on amines, steroids, and sapogenins.
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