闈舵爣锛欬p style="text-indent: 2em;">C11orf71

浜у搧鍒悕锛欬p style="text-indent: 2em;">URLC7锛 C11orf71锛 chromosome 11 open reading frame 71锛 chromosome 11 open reading frame 71锛 uncharacterized protein C11orf71锛 up-regulated in lung cancer 7锛 11鍙锋煋鑹蹭綋寮€鏀鹃槄璇绘71锛

鑳屾櫙淇℃伅锛欬div style="text-indent: 2em;">C11orf71, also known as FLJ20010, is a 123 amino acid protein that exists as two alternatively spliced isoforms and is encoded by a gene located on human chromosome 11. With approximately 135 million base pairs and 1,400 genes, chromosome 11 makes up around 4% of human genomic DNA and is considered a gene and disease association dense chromosome. The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double strand DNA breaks. Atm mutation leads to the disorder known as ataxia-telangiectasia. The blood disorders Sickle cell anemia and ?? thalassemia are caused by HBB gene mutations. Wilms' tumors, WAGR syndrome and Denys-Drash syndrome are associated with mutations of the WT1 gene. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11.