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鸟嘌呤核苷酸交换因子GEFT抗体
半岛bd体育手机客户端 介绍
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Arhgef25 半岛bd体育手机客户端 别名： 2410008H17Rik； D10Ertd610e； GEFT； Arhgef25； Rho guanine nucleotide exchange factor (GEF) 25； Rho guanine nucleotide exchange factor (GEF) 25； rho guanine nucleotide exchange factor 25； guanine nucleotide exchange factor GEFT； p63RhoGEF； rac/Cdc42/Rho exchange factor GEFT； rhoA/Rac/Cdc42 guanine nucleotide exchange factor GEFT； 鸟嘌呤核苷酸交换因子GEFT； 背景信息：
GEFT is a 580 amino acid cytoplasmic protein that is highly expressed in excitable tissues such as brain, heart and muscle, and weakly expressed in small intestine, colon, liver, placenta and lung. GEFT may play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. GEFT works as a guanine nucleotide exchange factor for the Rho family of small GTPases and links specifically to G alpha q 11-coupled receptors in Rho A activation. GEFT is an important regulator of processes involved in axon and dendrite formation. Involved in skeletal myogenesis, GEFT seems to be an exchange factor primarily for Rac 1 in neurons. Existing as two alternatively spliced variants, GEFT contains a DH (DBL-homology) domain and a PH domain.
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