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鸟氨酸脱羧酶抗酶3抗体
半岛bd体育手机客户端 介绍
靶标:
OAZ3 半岛bd体育手机客户端 别名: AZ3; OAZ-t; TISP15; OAZ3; ornithine decarboxylase antizyme 3; ornithine decarboxylase antizyme 3; ornithine decarboxylase antizyme 3; ODC-Az 3; antizyme 3; testicular secretory protein Li 31; 鸟氨酸脱羧酶抗酶3; 背景信息:
The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 3, the third member of the antizyme family. Like antizymes 1 and 2, antizyme 3 inhibits ODC activity and polyamine uptake; however, it does not stimulate ODC degradation. Also, while antizymes 1 and 2 have broad tissue distribution, expression of antizyme 3 is restricted to haploid germ cells in testis, suggesting a distinct role for this antizyme in spermiogenesis. Antizyme 3 gene knockout studies showed that ho
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