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原钙粘附蛋白12/血管内皮钙粘蛋白2抗体
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介绍 靶标: PCDH12 半岛bd体育手机客户端 别名: DMJDS1; VE-cadherin-2; VECAD2; PCDH12; protocadherin 12; protocadherin 12; protocadherin-12; VE-cad-2; VE-cadherin 2; vascular cadherin-2; vascular endothelial cadherin 2; 原钙粘附蛋白12/血管内皮钙粘蛋白2; 原钙黏素12(PCDH12); 背景信息: Protocadherins comprise the largest group within the cadherin family of calcium-dependent cell-cell adhesion molecules. Protocadherin 12 (PCDH12) was initially identified through PCR screening of mouse heart microvascular endothelial cell RNA; further experiments revealed its mRNA to be strongly expressed in highly vascularized organs such as lung and kidney, in addition to glycogen-rich trophoblasts in the placenta. PCDH12-null mice are viable and fertile, but show reduced placental and embryonic sizes when compared to wild-type mice. Further studies showed significant expression changes in 2, 289 genes, including those involved in tissue morphogenesis, angiogenesis, cell-matrix adhesion and migration, immune response and chromatin remodeling. 宿主:Rbt |
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