半岛bd体育手机客户端 介绍
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ATP6V0A4 半岛bd体育手机客户端 别名： A4； ATP6N1B； ATP6N2； DRTA3； RDRTA2； RTA1C； RTADR； STV1； VPH1； VPP2； ATP6V0A4； ATPase H+ transporting V0 subunit a4； ATPase H+ transporting V0 subunit a4； V-type proton ATPase 116 kDa subunit a 4； ATPase, H+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 1B； ATPase, H+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 2 (38kD)； ATPase, H+ transporting, lysosomal V0 subunit a4； H(+)-transporting two-sector ATPase, noncatalytic accessory protein 1B； V-ATPase 116 kDa； V-ATPase 116 kDa isoform a 4； V-ATPase subunit a4； V-type proton ATPase 116 kDa subunit a； vacuolar proton pump 116 kDa accessory subunit； vacuolar proton pump, subunit 2； 背景信息：
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. This gene is one of four genes in man and mouse that encode different isoforms of the a subunit. Alternatively spliced transcript variants encoding the same protein have been described. Mutations in this gene are associated with renal tubular acidosis associated with preserved hearing.
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