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DNA修复甲基磺酸敏感性基因19抗体
半岛bd体育手机客户端 介绍
靶标:
Mms19 半岛bd体育手机客户端 别名: CG12005; Dmel\CG12005; MMS19; NEST:bs07f08; dMMS19; mms19; Mms19; Mms19; Mms19; CG12005-PB; Mms19-PB; DNA修复甲基磺酸敏感性基因19; 背景信息:
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2 XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2 XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery.
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