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Taz抗体
半岛bd体育手机客户端 介绍
靶标:
Taz 半岛bd体育手机客户端 别名: CG8766; Dmel\CG8766; TAZ; dTAZ; tafazzin; taz; Taz; Tafazzin; Tafazzin; tafazzin; CG8766-PA; CG8766-PB; CG8766-PC; CG8766-PD; Taz-PA; Taz-PB; Taz-PC; Taz-PD; tafazzins; 背景信息:
Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3 MST2 and STK4 MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1 2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1 TAZ. WWTR1 enhances PAX8 and NKX2-1 TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.
宿主:Rbt |
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