半岛bd体育手机客户端 介绍
靶标：
SIT1 半岛bd体育手机客户端 别名： SIT； SIT-R； SIT1； signaling threshold regulating transmembrane adaptor 1； signaling threshold regulating transmembrane adaptor 1； signaling threshold-regulating transmembrane adapter 1； SHP-2 interacting transmembrane adaptor protein； SHP2 interacting transmembrane adaptor； SHP2-interacting transmembrane adapter protein； SHP2-interacting transmembrane adaptor protein； gp30/40； suppression inducing transmembrane adaptor 1； suppression-inducing transmembrane adapter 1； 信号阈值调节跨膜衔接因子1(SIT1)； 跨膜接头蛋白SIT； 背景信息：
SIT (SHP2-interacting transmembrane adaptor protein) is expressed exclusively in lymphoid organs and acts either as a positive or as a negative regulatory element in T cell activation and in T cell development. Binding to Grb2 plays a pivotal role in signal transduction. Hubener et al. (2001) determined that the SIT gene contains 5 exons and spans 1.8 kb of genomic DNA. The SIT promoter demonstrated strong transcriptional activity and potential binding sites for both ubiquitous and lymphoid-specific transcription factors.
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