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FGD2蛋白抗体
FGD2蛋白抗体图片
交货期: 1周
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交货期: 1周
半岛bd体育手机客户端 别名: Anti-Fgd2
Anti-FYVE, RhoGEF and PH domain containing 2 Antibody
半岛bd体育手机客户端 介绍
靶标:

Fgd2


半岛bd体育手机客户端 别名:

Tcd-2; Tcd2; ZFYVE4; tcs-2; tcs2; Fgd2; FYVE, RhoGEF and PH domain containing 2; FYVE, RhoGEF and PH domain containing 2; FYVE, RhoGEF and PH domain-containing protein 2; Fgd1 family, member 2; Fgd2-like protein; faciogenital dysplasia homolog 2; faciogenital dysplasia protein 2; t-complex distorter 2; FGD2蛋白;


背景信息:
Members of the Fgd (faciogenital dysplasia) gene family encode a group of critical guanine nucleotide exchange factors (GEFs), which, by specifically activating Cdc42, control cytoskeleton-dependent membrane rearrangements. In its first characterization, we find that FGD2 is expressed in antigen-presenting cells, including B lymphocytes, macrophages, and dendritic cells. In the B lymphocyte lineage, FGD2 levels change with developmental stage. In both mature splenic B cells and immature bone marrow B cells, FGD2 expression is suppressed upon activation through the B cell antigen receptor. FGD2 has a complex intracellular localization, with concentrations found in membrane ruffles and early endosomes. Although endosomal localization of FGD2 is dependent on a conserved FYVE domain, its C-terminal pleckstrin homology domain mediates recruitment to membrane ruffles. FGD2 overexpression promotes the activation of Cdc42 and leads to elevated JNK1 activity in a Cdc42- but not Rac1-dependent fashion. In several cases of familial glucocorticoid deficiency (FGD), referred to as FGD type 1, mutations have been described in the coding exon of the adrenocorticotropin receptor (melanonocortin receptor type 2, MC2R) gene. However, for the majority of cases (FGD type 2), no mutations were found in this gene.

宿主:Rbt
类型:Pab
同种型:IgG
应用:WB
纯化方式:亲和纯化
偶联物:Unconjugated
性状:液体
存储溶液:参阅说明书
浓度:Batch dependent (Please refer to the vial label for the specific concentration.)
稀释比例: Optimal dilutions/concentrations should be determined by the end user
储存:经常使用则4°C保存。-20°C保存不超过两年。避免反复冻融。
注意事项:仅供实验室使用。不适用于人类或动物的任何临床,治疗或诊断用途。不适合动物或人类食用。

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