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锌指蛋白451抗体
半岛bd体育手机客户端 介绍
靶标:
ZNF451 半岛bd体育手机客户端 别名: COASTER; ZATT; dJ417I1.1; ZNF451; zinc finger protein 451; zinc finger protein 451; E3 SUMO-protein ligase ZNF451; E3 SUMO-protein transferase ZNF451; coactivator for steroid receptors; zinc finger protein associated with TDP2 and TOP2; 锌指蛋白451; 背景信息:
E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins. Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro. Required for MCM4 sumoylation (By similarity. Has no activity with SUMO1. Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11'. Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9'. Plays a role in regulating the transcription of AR targets.
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