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Arih1抗体
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交货期: 1周
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交货期: 1周
半岛bd体育手机客户端 别名: Anti-Arih1
Anti-ariadne RBR E3 ubiquitin protein ligase 1 Antibody
半岛bd体育手机客户端 介绍
靶标:

Arih1


半岛bd体育手机客户端 别名:

AU021774; Ari; Ari1; Hari; Hhari; Ubch7bp; Uip77; Arih1; ariadne RBR E3 ubiquitin protein ligase 1; ariadne RBR E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase ARIH1; ARI-1; RING-type E3 ubiquitin transferase ARIH1; UbcH7-binding protein; UbcM4-interacting protein 77; ariadne 1; ariadne ubiquitin-conjugating enzyme E2 binding protein homolog 1; protein ariadne-1 homolog; ubiquitin-conjugating enzyme E2-binding protein 1;


背景信息:
E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3. Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets. The initial ubiquitin is then elongated by CDC34/UBE2R1 and UBE2R2. E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin-RING ubiquitin ligase complexes. Plays a role in protein translation in response to DNA damage by mediating ubiquitination of EIF4E2, the consequences of EIF4E2 ubiquitination are however unclear. According to a report, EIF4E2 ubiquitination leads to promote EIF4E2 cap-binding and protein translation arrest. According to another report EIF4E2 ubiquitination leads to its subsequent degradation. Acts as the ligase involved in ISGylation of EIF4E2. In vitro, controls the degradation of the LINC (LInker of Nucleoskeleton and Cytoskeleton complex member SUN2 and may therefore have a role in the formation and localization of the LINC complex, and as a consequence, nuclear subcellular localization and nuclear morphology.

宿主:Rbt
类型:Pab
同种型:IgG
应用:WB
纯化方式:亲和纯化
偶联物:Unconjugated
性状:液体
存储溶液:参阅说明书
浓度:Batch dependent (Please refer to the vial label for the specific concentration.)
稀释比例: Optimal dilutions/concentrations should be determined by the end user
储存:经常使用则4°C保存。-20°C保存不超过两年。避免反复冻融。
注意事项:仅供实验室使用。不适用于人类或动物的任何临床,治疗或诊断用途。不适合动物或人类食用。

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