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肌萎缩侧索硬化症相关蛋白HECW1抗体
半岛bd体育手机客户端 介绍
靶标：
HECW1 半岛bd体育手机客户端 别名： NEDL1； HECW1； HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1； HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1； E3 ubiquitin-protein ligase HECW1； HECT type E3 ubiquitin ligase； HECT-type E3 ubiquitin transferase HECW1； NEDD4-like ubiquitin-protein ligase 1； 肌萎缩侧索硬化症相关蛋白HECW1； 背景信息：
function:E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 C2 domain.,similarity:Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.,similarity:Contains 2 WW domains.,subunit:Interacts with DVL1 and SSR3. Also interacts with mutant SOD1.,tissue specificity:Predominantly expressed in neurons of adult and fetal brain. Weakly expressed in the kidney.,
宿主：Rbt |
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