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PHLPP2抗体
半岛bd体育手机客户端 介绍
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PHLPP2 半岛bd体育手机客户端 别名： PHLPPL； PPM3B； PHLPP2； PH domain and leucine rich repeat protein phosphatase 2； PH domain and leucine rich repeat protein phosphatase 2； PH domain leucine-rich repeat-containing protein phosphatase 2； protein phosphatase, Mg2+/Mn2+ dependent 3B； 背景信息：
PHLPP2 Antibody: PHLPP2 is a member of the serine/threonine phosphatase family, which are important regulators of Akt serine-threonine kinases (AKT1, AKT2, AKT3) and conventional/novel protein kinase C (PKC) isoforms. PHLPP1 and PHLPP2 have a similar domain structure and have been shown to dephosphorylate and inactivate, distinct Akt isoforms, at one of the two critical phosphorylation sites required for activation: Serine473. PHLPP2 dephosphorylates AKT1 and AKT3, whereas PHLPP1 is specific for AKT2 and AKT3. PHLPP1 promotes apoptosis and may act as a tumor suppressor. PHLPP2 associates with and is inhibited by adenylyl cyclase type 6 (AC6), thereby allowing Akt activation.
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