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液泡蛋白分选受体SORCS3抗体
半岛bd体育手机客户端 介绍
靶标:
SORCS3 半岛bd体育手机客户端 别名: SORCS; SORCS3; sortilin related VPS10 domain containing receptor 3; sortilin related VPS10 domain containing receptor 3; VPS10 domain-containing receptor SorCS3; VPS10 domain receptor protein SORCS 3 (SORCS3); 液泡蛋白分选受体SORCS3; 背景信息:
This gene encodes a type-I receptor transmembrane protein that is a member of the vacuolar protein sorting 10 receptor family. Proteins of this family are defined by a vacuolar protein sorting 10 domain at the N-terminus. The N-terminal segment of this domain has a consensus motif for proprotein convertase processing, and the C-terminal segment of this domain is characterized by ten conserved cysteine residues. The vacuolar protein sorting 10 domain is followed by a leucine-rich segment, a transmembrane domain, and a short C-terminal cytoplasmic domain that interacts with adaptor molecules. The transcript is expressed at high levels in the brain, and candidate gene studies suggest that genetic variation in this gene is associated with Alzheimer's disease. Consistent with this observation, knockdown of the gene in cell culture results in an increase in amyloid pre
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