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原蛋白转化酶4抗体
原蛋白转化酶4抗体图片
交货期: 1周
索取资料及报价
交货期: 1周
半岛bd体育手机客户端 别名: Anti-Pcsk4
Anti-proprotein convertase subtilisin/kexin type 4 Antibody
半岛bd体育手机客户端 介绍
靶标:

Pcsk4


半岛bd体育手机客户端 别名:

AI647044; L21221; NEC 3; NEC3; PC4; SPC5; Pcsk4; proprotein convertase subtilisin/kexin type 4; proprotein convertase subtilisin/kexin type 4; proprotein convertase subtilisin/kexin type 4; KEX2-like endoprotease 3; neuroendocrine convertase 3; prohormone convertase 3; 原蛋白转化酶4;


背景信息:
PCSK4(Proprotein Convertase, Subtilisin/Kexin-Type, 4), is an enzyme that in humans is encoded by the PCSK4 gene. The gene for PC4(Pcsk4 locus) was mapped to mouse chromosome 10, close to the adipsin locus and near the gene encoding anti-mullerian hormone. Qiu et al.(2005) found that aberrant processing of pro-IGF2 by PC4 may be a cause of IUGR. PC4 cleaved pro-IGF2 to generate the intermediate processed form, IGF2(1-102). Mature IGF2(1-67), likely resulting from further processing by carboxypeptidases, is capable of activating invasive trophoblast cells through AKT phosphorylation. Inhibition of PC4 by a PC4-specific inhibitor blocked pro-IGF2 processing and reduced trophoblast cell migration.

宿主:Rbt
类型:Pab
同种型:IgG
应用:WB
纯化方式:亲和纯化
偶联物:Unconjugated
性状:液体
存储溶液:参阅说明书
浓度:Batch dependent (Please refer to the vial label for the specific concentration.)
稀释比例: Optimal dilutions/concentrations should be determined by the end user
储存:经常使用则4°C保存。-20°C保存不超过两年。避免反复冻融。
注意事项:仅供实验室使用。不适用于人类或动物的任何临床,治疗或诊断用途。不适合动物或人类食用。

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