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前列腺素E受体4相关蛋白抗体
半岛bd体育手机客户端 介绍
靶标:
Fem1a 半岛bd体育手机客户端 别名: AW611390; Eprap; Fem1aa; Fem1a; fem 1 homolog a; fem 1 homolog a; protein fem-1 homolog A-A; FEM1-alpha-A; FEM1a-A; feminization 1 homolog a; prostaglandin E receptor 4-associated protein; 前列腺素E受体4相关蛋白; 背景信息:
Substrate-recognition component of a Cul2-RING (CRL2 E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(FEM1A complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons, such as SIL1 or OR51B2, leading to their ubiquitination and degradation. Promotes ubiquitination and degradation of SLBP. Involved in PGE2-EP4-mediated inhibition of inflammation of macrophages via interaction with NFKB1 and PTGER4 (By similarity. Promotes inflammation in brain microglia through MAP2K4/MKK4-mediated signaling (By similarity.
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