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USP20抗体
半岛bd体育手机客户端 介绍
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USP20 半岛bd体育手机客户端 别名： LSFR3A； VDU2； hVDU2； USP20； ubiquitin specific peptidase 20； ubiquitin specific peptidase 20； ubiquitin carboxyl-terminal hydrolase 20； deubiquitinating enzyme 20； pVHL-interacting deubiquitinating enzyme 2； ubiquitin thioesterase 20； ubiquitin thiolesterase 20； ubiquitin-specific-processing protease 20； 背景信息：
This gene encodes a ubiquitin specific processing protease that was first identified as a substrate of the VHL (von Hippel-Lindau disease) protein E3 ubiquitin ligase complex. In addition to being ubiquitinated by the VHL-E3 ligase complex, this enzyme deubiquitinates hypoxia-inducible factor (HIF)-1 alpha and thereby causes increased expression of HIF-1alpha targeted genes which play a role in angiogenesis, glucose metabolism, cell proliferation and metastasis. The enzyme encoded by this gene also regulates G-protein coupled receptor signaling by mediating the deubiquitination of beta-2 adrenergic receptor (ADRB2). This enzyme is a ubiquitously expressed thiolester hydrolase. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jan 2013],
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