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1号染色体开放阅读框2抗体
半岛bd体育手机客户端 介绍
靶标:
ENTREP3 半岛bd体育手机客户端 别名: C1orf2; COTE1; FAM189B; ENTREP3; endosomal transmembrane epsin interactor 3; endosomal transmembrane epsin interactor 3; protein FAM189B; family with sequence similarity 189 member B; 1号染色体开放阅读框2; 背景信息:
COTE1, also known as FAM189B (family with sequence similarity 189, member B), is a 668 amino acid multi-pass membrane protein that is widely expressed and belongs to the FAM189 family. Existing as two alternatively spliced isoforms, COTE1 is encoded by a gene that maps to human chromosome 1q22. As the largest human chromosome, chromosome 1 spans about 260 million base pairs and makes up approximately 8% of the human genome. Hutchinson-Gilford progeria, a rare aging disorder, is associated with the LMNA gene which is located on chromosome 1. Familial adenomatous polyposis, Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma.
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