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DR1相关蛋白1抗体
半岛bd体育手机客户端 介绍
靶标:
DRAP1 半岛bd体育手机客户端 别名: NC2-alpha; DRAP1; DR1 associated protein 1; DR1 associated protein 1; dr1-associated corepressor; negative co-factor 2-alpha; negative cofactor 2 alpha; DR1相关蛋白1; 背景信息:
Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex. [provided by RefSeq, Jul 2008]
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