闈舵爣锛欬p style="text-indent: 2em;">TCIRG1

浜у搧鍒悕锛欬p style="text-indent: 2em;">ATP6N1C锛 ATP6V0A3锛 Atp6i锛 OC-116kDa锛 OC116锛 OPTB1锛 Stv1锛 TIRC7锛 Vph1锛 a3锛 TCIRG1锛 T cell immune regulator 1, ATPase H+ transporting V0 subunit a3锛 T cell immune regulator 1, ATPase H+ transporting V0 subunit a3锛 V-type proton ATPase 116 kDa subunit a 3锛 ATPase, H+ transporting, 116kD锛 T-cell immune response cDNA 7锛 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein a锛 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3锛 V-ATPase 116 kDa subunit a 3锛 V-ATPase 116 kDa subunit a3锛 V-ATPase 116-kDa锛 V-ATPase subunit a3锛 V-type proton ATPase 116 kDa subunit a锛 V-type proton ATPase 116 kDa subunit a3锛 osteoclastic proton pump 116 kDa subunit锛 specific 116-kDa vacuolar proton pump subunit锛 vacuolar proton translocating ATPase 116 kDa subunit A锛 T-缁嗚優鍏嶇柅璋冭妭鍥犲瓙1(TCIRG1)锛

鑳屾櫙淇℃伅锛欬div style="text-indent: 2em;">This gene encodes a subunit of a large protein complex known as a vacuolar H+-ATPase (V-ATPase). The protein complex acts as a pump to move protons across the membrane. This movement of protons helps regulate the pH of cells and their surrounding environment. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. V-ATPase is comprised of a cytosolic V1 domain and a transmembrane V0 domain. Alternative splicing results in multiple transcript variants. Mutations in this gene are associated with infantile malignant osteopetrosis.