闈舵爣锛欬p style="text-indent: 2em;">APC2

浜у搧鍒悕锛欬p style="text-indent: 2em;">APCL锛 MRT74锛 APC2锛 APC regulator of WNT signaling pathway 2锛 APC regulator of WNT signaling pathway 2锛 adenomatous polyposis coli protein 2锛 APC2, WNT signaling pathway regulator锛 adenomatosis polyposis coli 2锛 adenomatous polyposis coli like锛

鑳屾櫙淇℃伅锛欬div style="text-indent: 2em;">APC2, which is also called APCL, is a deduced 2,303-amino acid protein that contains an N-terminal coiled-coil domain, followed by an armadillo domain and five 20-amino acid repeats. The human APC2 gene is mapped to chromosome 19p13.3. It is found that the 20-amino acid repeat domain of APCL could bind beta-catenin (CTNNB1) and deplete the intracellular beta-catenin pool. A reporter gene assay revealed that APCL could regulate interaction of beta-catenin with T cell-specific transcription factors (TCF7), although less efficiently than APC.