半岛bd体育手机客户端 介绍
靶标：
ASAP2 半岛bd体育手机客户端 别名： AMAP2； CENTB3； DDEF2； PAG3； PAP； Pap-alpha； SHAG1； ASAP2； ArfGAP with SH3 domain, ankyrin repeat and PH domain 2； ArfGAP with SH3 domain, ankyrin repeat and PH domain 2； arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2； PYK2 C terminus-associated protein； centaurin, beta 3； development and differentiation-enhancing factor 2； paxillin-associated protein with ARF GAP activity 3； pyk2 C-terminus-associated protein； 发育和分化增强因子PAG3； 背景信息：
This gene encodes a multidomain protein containing an N-terminal alpha-helical region with a coiled-coil motif, followed by a pleckstrin homology (PH) domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-terminal Src homology 3 (SH3) domain. The protein localizes in the Golgi apparatus and at the plasma membrane, where it colocalizes with protein tyrosine kinase 2-beta (PYK2). The encoded protein forms a stable complex with PYK2 in vivo. This interaction appears to be mediated by binding of its SH3 domain to the C-terminal proline-rich domain of PYK2. The encoded protein is tyrosine phosphorylated by activated PYK2. It has catalytic activity for class I and II ArfGAPs in vitro, and can bind the class III Arf ARF6 without immediate GAP activity. The encoded protein is believed to function as an ARF GAP that controls ARF-mediated vesicle
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