闈舵爣锛欬p style="text-indent: 2em;">TAF6

浜у搧鍒悕锛欬p style="text-indent: 2em;">ALYUS锛 MGC:8964锛 TAF(II)70锛 TAF(II)80锛 TAF2E锛 TAFII-70锛 TAFII-80锛 TAFII70锛 TAFII80锛 TAFII85锛 TAF6锛 TATA-box binding protein associated factor 6锛 TATA-box binding protein associated factor 6锛 transcription initiation factor TFIID subunit 6锛 RNA polymerase II TBP-associated factor subunit E锛 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa锛 TATA box binding protein (TBP)-associated factor, RNA polymerase II, E, 70/85kD锛 transcription initiation factor TFIID 70 kDa subunit锛 杞綍璧峰鍥犲瓙TFIID浜氬熀6锛

鑳屾櫙淇℃伅锛欬div style="text-indent: 2em;">Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds weakly to TBP but strongly to TAF1, the largest subunit of TFIID. Alternative splicing results in multiple transcript variants.