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磷酸二酯酶6β抗体
半岛bd体育手机客户端 介绍
靶标:
PDE6B 半岛bd体育手机客户端 别名: CSNB3; CSNBAD2; GMP-PDEbeta; PDEB; RP40; rd1; PDE6B; phosphodiesterase 6B; phosphodiesterase 6B; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta; GMP-PDE beta; phosphodiesterase 6B, cGMP-specific, rod, beta; rod cGMP-phosphodiesterase beta-subunit; 磷酸二酯酶6β; 背景信息:
Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene.
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