半岛bd体育手机客户端 介绍
靶标：
KIR2DS5 半岛bd体育手机客户端 别名： CD158G； NKAT9； KIR2DS5； killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 5； killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 5； killer cell immunoglobulin-like receptor 2DS5； CD158 antigen-like family member G； NKAT-9； killer Ig receptor； killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5； natural killer cell inhibitory receptor； natural killer-associated transcript 9； 背景信息：
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the
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