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HLA-DRB3抗体
HLA-DRB3抗体图片
交货期: 1周
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交货期: 1周
半岛bd体育手机客户端 别名: Anti-HLA-DRB3
Anti-major histocompatibility complex, class II, DR beta 3 Antibody
半岛bd体育手机客户端 介绍
靶标:

HLA-DRB3


半岛bd体育手机客户端 别名:

DRB3; HLA-DPB1; HLA-DR1B; HLA-DR3B; HLA-DRB3*; HLA-DRB3; major histocompatibility complex, class II, DR beta 3; major histocompatibility complex, class II, DR beta 3; major histocompatibility complex, class II, DR beta 3; HLA DRB3; HLA class II histocompatibility antigen, DR beta 3 chain; MHC class II DR beta chain; MHC class II HLA-DR beta 3 chain; MHC class II antigen DR beta 3 chain; MHC class II antigen DRB3; MHC class II protein; human leucocyte antigen DRB3; major histocompatibility complex, class II, DRB3;


背景信息:
HLA-DRB3 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB3 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.

宿主:Rbt
类型:Pab
同种型:IgG
应用:WB
纯化方式:亲和纯化
偶联物:Unconjugated
性状:液体
存储溶液:参阅说明书
浓度:Batch dependent (Please refer to the vial label for the specific concentration.)
稀释比例: Optimal dilutions/concentrations should be determined by the end user
储存:经常使用则4°C保存。-20°C保存不超过两年。避免反复冻融。
注意事项:仅供实验室使用。不适用于人类或动物的任何临床,治疗或诊断用途。不适合动物或人类食用。

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