闈舵爣锛欬p style="text-indent: 2em;">HBA2

浜у搧鍒悕锛欬p style="text-indent: 2em;">ECYT7锛 HBA-T2锛 HBH锛 HBA2锛 hemoglobin subunit alpha 2锛 hemoglobin subunit alpha 2锛 hemoglobin subunit alpha锛 alpha globin锛 alpha-2 globin锛 hemoglobin alpha chain锛 hemoglobin, alpha 2锛 mutant hemoglobin alpha 2 globin chain锛

鑳屾櫙淇℃伅锛欬div style="text-indent: 2em;">The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1; some nondeletion alpha thalassemias have also been reported.