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胎儿阿兹海默病抗原/核小体重塑因子抗体
半岛bd体育手机客户端 介绍
靶标：
BPTF 半岛bd体育手机客户端 别名： FAC1； FALZ； NEDDFL； NURF301； BPTF； bromodomain PHD finger transcription factor； bromodomain PHD finger transcription factor； nucleosome-remodeling factor subunit BPTF； bromodomain and PHD domain transcription factor； bromodomain and PHD finger-containing transcription factor； fetal Alz-50 clone 1 protein； fetal Alz-50 reactive clone 1； fetal Alzheimer antigen； nucleosome remodeling factor, large subunit； 胎儿阿兹海默病抗原/核小体重塑因子； 背景信息：
This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome
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